Gene expression profiling of African-American prostate cancer

ABSTRACT: African-American (AA) men have both a higher incidence and significantly higher mortality rates from prostate cancer (PCa) than European American (EA) men. In this study we have carried out a detailed analysis of both CNAs and gene expression changes in PCas from AA men compared to their matched benign tissues. We have identified MNX1 as a novel androgen regulated oncogene that is upregulated to a greater degree in AA PCa compared to EA PCa. Furthermore, RGS12 is a novel tumor suppressor on 4p16.3 that is preferentially deleted in AA PCa which negatively regulates MNX1 expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71016 | GEO | 2016/08/31

SECONDARY ACCESSION(S): PRJNA290106

REPOSITORIES: GEO