Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The dynamic regulatory genome of Capsaspora owczarzaki and the origin of animal multicellularity

ABSTRACT: We carried out multiple functional genomic assays in Capsaspora owczarzaki, the unicellular relative of animals with the largest known gene repertoire for transcriptional regulation. We show that changing chromatin states, differential lincRNA expression and dynamic cis-regulatory sites are associated with life cycle transitions in Capsaspora.

ORGANISM(S): Capsaspora owczarzaki

PROVIDER: GSE71131 | GEO | 2016/04/12

SECONDARY ACCESSION(S): PRJNA290432

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

The dynamic regulatory genome of Capsaspora owczarzaki and the origin of animal multicellularity

Project description:Recent evidence that the unicellular ancestor of animals had a complex repertoire of genes linked to multicellular processes suggests that changes in the regulatory genome, rather than gene innovation, were key to the origin of animals. Here, we carry out multiple functional genomic assays in Capsaspora owczarzaki, the unicellular relative of animals with the largest known gene repertoire for transcriptional regulation. We show that changing chromatin states, differential lincRNA expression and dynamic cis-regulatory sites are associated with life cycle transitions in Capsaspora. Moreover, we demonstrate conservation of animal developmental transcription factor networks and extensive network interconnection in this premetazoan organism. In contrast, however, Capsaspora lacks animal promoter types and its regulatory sites are small, proximal and lack signatures of animal enhancers. Overall, our results indicate that the emergence of animal multicellularity was linked to a major shift in genome regulatory complexity, most notably the appearance of distal enhancer regulation.

2018-10-24 | PXD002342 | Pride

The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity.

Project description: Not available

| S-EPMC4877666 | biostudies-literature

The Origin of Animal Multicellularity and Cell Differentiation.

Project description: Not available

| S-EPMC6089241 | biostudies-literature

Phosphotyrosine signalling and the origin of animal multicellularity.

Project description: Not available

| S-EPMC5563799 | biostudies-literature

The origin of multicellularity in cyanobacteria.

Project description: Not available

| S-EPMC3271361 | biostudies-literature

Animal multicellularity and polarity without Wnt signaling.

Project description: Not available

| S-EPMC5684314 | biostudies-literature

High-throughput Proteomics Reveals the Unicellular Roots of Animal Phosphosignaling and Cell Differentiation

Project description:Cell-specific regulation of protein levels and activity is essential for the distribution of functions among multiple cell types in animals. The finding that many genes involved in these regulatory processes have a premetazoan origin raises the intriguing possibility that the mechanisms required for spatially regulated cell differentiation evolved prior to the appearance of animals. Here, we use high-throughput proteomics in Capsaspora owczarzaki, a close unicellular relative of animals, to characterize the dynamic proteome and phosphoproteome profiles of three temporally distinct cell types in this premetazoan species. We show that life-cycle transitions are linked to extensive proteome and phosphoproteome remodeling and that they affect key genes involved in animal multicellularity, such as transcription factors and tyrosine kinases. The observation of shared features between Capsaspora and metazoans indicates that elaborate and conserved phosphosignaling and proteome regulation supported temporal cell-type differentiation in the unicellular ancestor of animals.

2016-11-30 | PXD004567 | Pride

The evolution of trade-offs between defense and reproduction facilitates the transition towards multicellularity

Project description:The evolutionary transition of multicellular life initially involves growth in groups of undifferentiated cells followed by differentiation into soma and germ-like cells. This is facilitated by trade-offs between traits determining survival and reproduction, favoring the coexistence of cells with extreme trait values and a convex trade-off curve as the multicellular state dominates. However, these transitions remain poorly characterized at the ecological and genetic level. Here, we studied the evolution of cell groups in ten isogenic lines of the unicellular green algae Chlamydomonas reinhardtii with prolonged exposure to a rotifer predator. We confirmed that this trait was heritable and characterized by a convex trade-off curve between reproduction and survival. Identical mutations evolved in all cell group isolates which were linked to survival and reducing associated cell costs. Overall, we show that just 500 generations of predator selection is sufficient to lead to a convex trade-off and incorporate evolved changes into the prey genome.

2021-02-13 | GSE166685 | GEO

Genetics of a de novo origin of undifferentiated multicellularity.

Project description: Not available

| S-EPMC6124120 | biostudies-literature

Comparative genomics reveals the origin of fungal hyphae and multicellularity.

Project description: Not available

| S-EPMC6733946 | biostudies-literature