Genomics

Dataset Information

17

Injury-induced enhancer remodelling in spinal microglia - a novel mechanism for pain chronification?


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Franziska Denk 

PROVIDER: GSE71136 | GEO | 2016-05-12

SECONDARY ACCESSION(S): PRJNA290434 GSE71133 GSE71134

REPOSITORIES: GEO

Dataset's files

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Publications

Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain.

Denk Franziska F   Crow Megan M   Didangelos Athanasios A   Lopes Douglas M DM   McMahon Stephen B SB  

Cell reports 20160512 8


Chronic pain is a common and devastating condition that induces well-characterized changes in neurons and microglia. One major unanswered question is why these changes should persist long after the precipitating injury has healed. Here, we suggest that some of the longer-lasting consequences of nerve injury may be hidden in the epigenome. Cell sorting and sequencing techniques were used to characterize the spinal cord immune response in a mouse model of chronic neuropathic pain. Infiltration of  ...[more]

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