Genomics

Dataset Information

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LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer [array]


ABSTRACT: HOTAIR is up-regulated in tamoxifen-resistant breast cancer tissues compared to their primary counterparts. Mechanistically, HOTAIR is a direct target of ER-mediated transcriptional repression and is thus restored upon the blockade of ER signaling, either by hormone deprivation or tamoxifen treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71297 | GEO | 2015/10/01

SECONDARY ACCESSION(S): PRJNA290857

REPOSITORIES: GEO

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