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5-aza treatment of breast cancer and non-tumorigenic breast cells

ABSTRACT: CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor gene silencing in various types of cancers. 5-aza-2'-deoxycytidine (AZA) is a DNA demethylating and anti-cancer agent resulting in induction of genes suppressed via DNA hypermethylation. Using microarray expression profiling of AZA or DMSO treated and untreated breast cancer (MCF7 and MDA-MB-231) and non-tumorigenic breast (NTB) cells, we aim to identify candidate genes that are downregulated via promoter hypermethylation in breast cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71363 | GEO | 2017/02/09

SECONDARY ACCESSION(S): PRJNA291042

REPOSITORIES: GEO

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