Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Paired copy number analysis of Diffuse Large B Cell Lymphoma

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71394 | GEO | 2016/01/22

SECONDARY ACCESSION(S): PRJNA291077

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data and Copy Number Variations from Diffuse Large B Cell Lymphoma (DLBCL) patients

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-09-05 | GSE136971 | GEO

Paired copy number analysis of Diffuse Large B Cell Lymphoma [OncoScan]

Project description:Copy number analysis can be useful for assessing prognosis in diffuse large B cell lymphoma (DLBCL). We analyzed copy number data from tumor samples of 60 patients diagnosed with DLBCL de novo and their matched normal samples. We detected a total of 63 recurrent copy number alterations (CNAs), including 33 gains, 30 losses, and nine recurrent acquired copy number neutral loss of heterozygosity (CNN-LOH). Interestingly, 20% of cases acquired CNN-LOH of 6p21 locus, which involves the HLA region. In normal cells there were no CNAs but we observed CNN-LOH involving some key lymphoma regions such as 6p21 and 9p24.1 (5%) and 17p13.1 (2.5%) in DLBCL patients. Furthermore, a model with some specific CNA was able to predict the subtype of DLBCL, 1p36.32 and 10q23.31 losses being restricted to germinal center B cell-like (GCB) DLBCL. In contrast, 8p23.3 losses and 11q24.3 gains were strongly associated with the non-GCB subtype. A poor prognosis was associated with biallelic inactivation of TP53 or 18p11.32 losses, while prognosis was better in cases carrying 11q24.3 gains, which includes ETS1 and FLI1 genes. In summary, CNA abnormalities identify specific DLBCL groups, and we describe CN-LOH in germline cells from DLBCL patients that are associated with genes that probably play a key role in DLBCL development.

2016-01-22 | GSE71386 | GEO

TET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-10-10 | E-GEOD-37365 | biostudies-arrayexpress

Correlation between STAT3 binding presence and gene expression levels in subtypes of diffuse large B cell lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-16 | E-GEOD-50724 | biostudies-arrayexpress

Transcriptional profiling of diffuse large B-cell lymphoma mouse models

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-06 | GSE197693 | GEO

Paired copy number analysis of DLBCL Diffuse Large B Cell Lymphoma [SNP 6.0 Array]

2016-01-22 | GSE71389 | GEO

Epigenetic priming using low-dose 5-azazcytidine in diffuse large B-cell lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-27 | GSE190321 | GEO

Epigenetic Gene Regulation by Janus Kinase 1 in Diffuse Large B Cell Lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-02-08 | GSE86266 | GEO

Transferring genomics to the clinic: distinguishing Burkitt and Diffuse large B-cell lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-09-30 | GSE69053 | GEO

The Landscape of Tumor Cell States and Ecosystems in Diffuse Large B Cell Lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-30 | GSE182436 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data