Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)
SUBMITTER: Peter J Park
PROVIDER: GSE71511 | GEO | 2016-11-21
SECONDARY ACCESSION(S): PRJNA291422
REPOSITORIES: GEO
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Mathur Radhika R Alver Burak H BH San Roman Adrianna K AK Wilson Boris G BG Wang Xiaofeng X Agoston Agoston T AT Park Peter J PJ Shivdasani Ramesh A RA Roberts Charles W M CW
Nature genetics 20161212 2
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in ∼20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here we demonstrate that Arid1a functions as a tumor suppressor in the mouse colon, but not the small intestine, and that invasive ARID1A-deficient adenocarcinomas resemble human colorectal cancer (CRC). These tumors lack deregulation of AP ...[more]