Transcriptomics,Genomics

Dataset Information

156

Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes


ABSTRACT: In this study we report the gene expression profile and MISO analysis for alternative splicing events such as exon skipping in iPSC-derived cardiomyocytes which were treated with a drug inhibiting α-ketoglutarate-dependent hydroxylases (dimethyloxalylglycine) and compared to vehicle control. α-ketoglutarate-dependent hydroxylase inhibition plays a central role in cardiac hypoxia and the goal of this study was to identify new pathways in hypoxia beyond HIF-1α. Overall design: Biological replicates of RNA-seq data from iPSC-derived cardiomyocytes treated with dimethyloxalylglycine or vehicle control

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Yanqin Yang  

PROVIDER: GSE71560 | GEO | 2016-05-05

SECONDARY ACCESSION(S): PRJNA291518

REPOSITORIES: GEO

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