RNA-sequencing of cells derived from the site of inflammation of Juvenile Idiopathic Arthritis patients

ABSTRACT: Through RNA sequencing of CD4+ Tmemory/effector cells derived from the synovium of JIA patients and healthy controls, we analyzed the JIA gene expression signature. Treatment of autoinflammatory site-derived patient T cells with the BET-inhibitor JQ1 inhibited immune-related super-enhancers and preferentially reduced disease-associated gene expression, including cytokine-related processes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71595 | GEO | 2015/09/15

SECONDARY ACCESSION(S): PRJNA291597

REPOSITORIES: GEO