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Genome-wide map of H3K4me3 before and after methionine restriction in HCT116 cells.

ABSTRACT: The goals of this study were to compare the distribution of H3K4me3 before and after methionine restriction to understand how nutrient availability and alterations in methionine metabolism affect the epigenetic state and regulate gene transcription. To do this we performed ChIP-seq with an H3K4me3 antibody and RNA-seq using PolyA+ mRNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE72131 | GEO | 2015/08/17

SECONDARY ACCESSION(S): PRJNA293125

REPOSITORIES: GEO

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Genome-wide H3K4me3 and gene expression before and after methionine restriction in human cancer cells and mouse liver

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scRNA-seq of aged Drosophila midgut under methionine restriction

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RNA sequencing analysis of HCT116 cells following 24 hours of metabolic recovery from methionine restriction +/- small molecule treatment.

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Genome-wide H3K4me3 and gene expression before and after methionine restriction in human cancer cells and mouse liver

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Effects of 20 months Dietary Methionine Restriction on Hepatic Gene Expression in Fischer 344 Rats

Project description:Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the liver. We analyzed MR-induced changes in gene expression using pooled RNA from liver of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.

2012-04-07 | E-GEOD-28482 | biostudies-arrayexpress

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Genome-wide maps of H3K9 PTMs in HCT116 cells before and after 24 hours of methionine restriction.

Project description:We determined H3K9me3 enrichment is lost at constitutively reppressed chromatin regions in response to 24 hours of methonine restriction and is subsequently replaced by H3K9me1.

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