Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Adipose tissue remodeling during drastic weight loss

ABSTRACT: The main aim of this experiment was to investigate gene expression on human subcutaneous adipose tissue following bariatric surgery. Our questions consisted in understanding how gene expression was linked to clinical parameters of obese patients and whether this drastic weight loss was discriminated this data.

ORGANISM(S): Homo sapiens

PROVIDER: GSE72158 | GEO | 2015/08/19

SECONDARY ACCESSION(S): PRJNA293219

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transcriptional profiling of subcutaneous adipose tissue of morbidly obese subjects before and after 2 years of bariatric surgery.

Project description:Transcriptional profiling of subcutaneous adipose tissue before and after 2 years of bariatric surgery. This type of surgery produce a masive weight loss in morbidly obese subjects, and improve the comorbidities associated to obesity. Goal was to determine the effects of bariatric surgery on the gene expression of subcutaneous adipose tissue.

2017-03-16 | GSE66921 | GEO

A Memory for Obesity in Adipose Tissue

Project description:To identify transcriptional alterations in subcutaneous human white adipose tissue of post-obese subjects, global gene expression measurements were performed. Three groups, obese before and after bariatric surgery as well as never-obese controls, were compared to dissect candidate genes.

2017-06-01 | GSE59034 | GEO

Impact of bariatric surgery on RNA-seq gene expression profiles of peripheral monocytes in humans

Project description:Genome-wide expression profiles in peripheral monocytes (PM) from 19 obese women before and 3 months after bariatric surgery using the RNA-seq technology. This dataset is linked to the dataset GSE65540 providing expression profiles in subcutaneous adipose tissue (SAT) in the same population. Due to exclusion of some individuals for technical reasons, the overlap between the 2 datasets is of 18 women. mRNA sequencing of peripheral monocyte (PM) samples from 19 obese women before and 3 months after bariatric surgery

2015-07-09 | E-GEOD-66306 | biostudies-arrayexpress

Next Generation Sequencing of liver and subcutaneous fat tissues obtained from obese subjects

2016-06-15 | GSE83322 | GEO

Epigenome analysis of the human subqutaneous adipose tissue

2014-09-17 | GSE61450 | GEO

Next Generation Sequencing of liver and subcutaneous fat tissues obtained from obese subjects

Project description:Patients had low calorie diet weight reduction run in prior to the day of surgery. The human liver and subcutaneous fat tissue samples were obtained from 12 obese subjects undergoing bariatric surgery and then used for the mRNA expression analyses. mRNA profiles of human liver and subcutaneous fat tissue samples were generated by RNA sequencing using Illumina HiSeq 2500. This dataset is part of the TransQST collection.

2016-06-15 | E-GEOD-83322 | biostudies-arrayexpress

Epigenome analysis of the human subqutaneous adipose tissue

Project description:Subcutaneous adipose tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to identify tissue specific methylation QTLs. Whole-transcriptome subcutaneous adipose tissue methylation levels were determined in 71 individuals with a BMI >35 kg/m2. Bisulphite converted DNA from the 71 subcutaneous adipose tissue samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip.

2014-09-17 | E-GEOD-61450 | biostudies-arrayexpress

Transcriptome analysis of circulating monocytes in obese patients before and three months after bariatric surgery

Project description:Low-grade chronic inflammation plays an important role in the development of obesity and obesity-associated disorders such as insulin resistance, type 2 diabetes, the metabolic syndrome and atherosclerosis. One possible link between obesity and inflammation is the enhanced activation of circulating monocytes making them more prone to infiltration into the adipose and vascular tissues of obese persons. Furthermore, weight loss after bariatric surgery is associated with less inflammation. Transcriptome analysis of circulating monocytes from control and obese patients before and after bariatric surgery will potentially provide insights into the pathophysiology of obesity and associated disorders and supply biomarkers for diagnostic purpose. The cohort comprised 6 lean age-matched controls (BMI: 20.3±0.5 kg/m2, mean±SEM) and 18 obese individuals without clinical symptoms of cardiovascular disease (BMI: 45.1±1.4 kg/m2, P<0.001 compared with lean controls). These 18 morbidly obese subjects were referred to our hospital for bariatric surgery. Before they were included, individuals were evaluated by an endocrinologist, an abdominal surgeon, a psychologist and a dietician. Only after multidisciplinary deliberation, the selected patients received a laparoscopic Roux-en-Y gastric bypass. CD14+ monocytes were collected before and three months after bariatric surgery (BMI: 37.5±1.3 kg/m2, P<0.001 compared with before weight loss), total RNA was extracted and subjected to genome-wide expression analysis. Samples consisted of CD14+ monocytes from 6 lean controls and 18 morbidly obese patients before and three months after bariatric surgery. The 6 lean controls were also used to make 6 control pools.

2012-05-23 | E-GEOD-32575 | biostudies-arrayexpress

Epigenome analysis of the human liver

Project description:Liver tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to identify tissue specific methylation QTLs. Whole-transcriptome subcutaneous adipose tissue methylation levels were determined in 67 individuals with a BMI >35 kg/m2.

2014-09-17 | GSE61446 | GEO

Epigenome analysis of the human muscle

Project description:Muscle tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to identify tissue specific methylation QTLs. Whole-transcriptome subcutaneous adipose tissue methylation levels were determined in 60 individuals with a BMI >35 kg/m2.

2014-09-17 | GSE61452 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data