Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MRNA expression data for rat liver treated for 24h with RG3487 (180mg/kg po.) vs vehicle only (deionized water)

ABSTRACT: Gene expression analysis followed by gene onthology pathway analysis revealed that “cell cycle” and “growth and proliferation” pathways were significantly affected in the high dose group at the 24h time point. No consistent gene expression changes related to nuclear receptor activation, in particular target genes of CAR, PXR or PPAR were observed at the 24h time point

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE72357 | GEO | 2015/08/26

SECONDARY ACCESSION(S): PRJNA293867

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

mRNA expression data for rat liver treated for 24h with RG3487 (180mg/kg po.) vs vehicle only (deionized water)

Project description:Gene expression analysis followed by gene onthology pathway analysis revealed that “cell cycle” and “growth and proliferation” pathways were significantly affected in the high dose group at the 24h time point. No consistent gene expression changes related to nuclear receptor activation, in particular target genes of CAR, PXR or PPAR were observed at the 24h time point Rat liver tissue was harvested 2h hours after treatment of rats with test compound or vehicle. Tissue was harvested in RNA-Later (Ambion Cat No 7021) for RNA extraction and hybridization to Affymetrix microarrays

2015-08-26 | E-GEOD-72357 | biostudies-arrayexpress

Mouse cardiac tissue: Vehicle treated control vs. 15mg/kg doxorubicin

Project description:Transcriptional profiling of mouse cardiac tissue treated with 15mg/kg doxorubicin in 10 ml/kg saline over an acute time course (0.5-120 hours) compared to time matched control animals treated with 10ml/kg saline. Two colour microarrays with time matched controls against 15mg/kg doxorubicin cardiac tissue. Time points studied were 0.5, 1, 2, 12, 24 and 120 hours following dosing, biological replicates n=>3 independent animals at each time point, technical replicate n>1 with reverse labelling at each time point. One array printed onto two slides (A and B), one replicate per array.

2010-08-06 | E-GEOD-17826 | biostudies-arrayexpress

Mouse cardiac tissue: Vehicle treated control vs. 25mg/kg DMNQ

Project description:Transcriptional profiling of mouse cardiac tissue treated with 25mg/kg DMNQ in 10 ml/kg arachis oil over an acute time course (5 minutes-120 hours) compared to time matached control animals treated with 10ml/kg arachis oil Two colour microarrays with time matched controls against 25mg/kg DMNQ cardiac tissue. Time points studied were 5, 10, 15, 20, 30, 45 minutes and 1, 1.5, 2, 5, 12, 24, 120 hours following dosing, biological replicates n=>2 independent animals at each time point, technical replicate n>1 with reverse labelling at each time point. One array printed onto two slides (A and B), one replicate per array.

2010-08-06 | E-GEOD-17915 | biostudies-arrayexpress

3'mRNA sequencing of hepatic RNA (MACE) at the time points 24h/48h after acetaminophen (APAP) (300mg/kg) administration

Project description:Hepatic RNA specimens from mice (C57BL/6) of the 4 groups (vehicle-treated at 24h/48h, n=6; acetaminophen (APAP)-treated (300mg/kg) at 24h/48h, n=7) were pooled at equal shares. Thereafter, pooled RNA underwent analysis by 3'mRNA sequencing (MACE, GenXPro, Frankurt, Germany).

2021-12-31 | GSE169071 | GEO

Androgen-starved LNCaP cells treated with gedunin and androgen, androgen alone, or vehicle alone for 24h

Project description:Gedunin is a natural product that affects LNCaP androgen-signalling by 24h We used microarrays to detail the androgen-responsive program of gene expression affected by gedunin treatment at 24h Keywords: drug treatment

2006-09-01 | GSE5508 | GEO

Androgen-starved LNCaP cells treated with celastrol and androgen, androgen alone, or vehicle alone for 24h

Project description:celastrol is a natural product that affects LNCaP androgen-signalling by 24h We used microarrays to detail the androgen-responsive program of gene expression affected by celastrol treatment at 24h Keywords: drug treatment

2006-09-01 | GSE5507 | GEO

MCF10A 24h unstimulated

Project description:Gene expression after cell culture, 24h unstimulated

| EGAD00010001962 | EGA

Mouse cardiac tissue: Vehicle treated control vs. 15mg/kg doxorubicin

2010-08-06 | GSE17826 | GEO

Mouse cardiac tissue: Vehicle treated control vs. 25mg/kg DMNQ

2010-08-06 | GSE17915 | GEO

Mouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 25mg/kg DMNQ

Project description:Translational profiling of mouse cardiac tissue treated with 25mg/kg DMNQ in 10 ml/kg arachis oil over an acute time course (0.5-120 hours) compared to time matched control animals treated with 10ml/kg saline Two colour microarrays with time matched controls vs 25mg/kg DMNQ cardiac tissue. Before microarray analysis RNA separated on a sucrose density gradient into those mRNAs activitly undergoing translation (polysomes) and those not (monosomes) with control monosomes and treated monosomes on one set of arrays, and polysome control and polysome treated on another set of microarrays. The normalized Log2 of the monosomes was subtracted from the respective Log2 of the polysomes (on Series record). Time points studied were 0.5, 1, 2, 12, 24 and 120 hours following dosing, biological replicates n=3 independent animals at each time point, technical replicates (reverse labelling) n<1. One array printed onto two slides (A and B), one replicate per array.

2010-08-06 | E-GEOD-17830 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data