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C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection

ABSTRACT: Whole-genome data was developed from influenza virus infected A549 cells to better characterize the effect of C646 on influenza virus infection

ORGANISM(S): Homo sapiens

PROVIDER: GSE72503 | GEO | 2016/01/07

SECONDARY ACCESSION(S): PRJNA294177

REPOSITORIES: GEO

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C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection

Project description:Whole-genome data was developed from influenza virus infected A549 cells to better characterize the effect of C646 on influenza virus infection A549 cells were treated with C646 or DMSO for 10 h, and then were infected with A/WSN/33 virus (WSN; H1N1) at a multiplicity of infection (MOI) 2. A549 cells for microarray studies were collected at different times. The gene expression in A549 cells was compared between C646-treated group and DMSO-treated group.

2016-01-07 | E-GEOD-72503 | biostudies-arrayexpress

C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection.

Project description: Not available

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Gene expression changes due to influenza virus induced miRNAs

Project description:The goal of this experiment was to determine gene expression changes during influenza A virus infection as the result of expression influenza virus inducible miRNAs in A549 cells. The gene expression profiling experiment was performed with 4 groups (mock infected, influenza A virus infected, influenza A virus infected in the presence of exogenous miR-141, miR-374b, miR-449b, miR-518b, and miR-1263, and influenza A virus infected in the presence of exogenous miR-147b, miR-190b, miR-199a, miR-512-5p, and miR-874 with 3 biological replicates for each group. Total RNA was purified from A549 cells that were mock infected or infected with influenza A virus (A/WSN/33, 5pfu/cell) alone or in the presence of miRNA mimics 10 hours after treatment.

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Gene expression changes due to influenza virus induced miRNAs

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MicroRNA profiling of influenza A virus infected cells

Project description:Small RNAs were profiled during influenza A virus infection of human A549 cells to identify changes in microRNA abundance during the cellular antiviral response. Examination of microRNA abundance during influenza A virus infection.

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Effect of Influenza virus infection on lncRNA expression in A549 cells

Project description:Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as discovered by sequencing techniques and follow-up functional studies. There are only few studies on lncRNAs as related to gene expression regulation and anti-viral activity during influenza virus infection. We sought to identify and characterize lncRNAs involved in influenza virus replication. In the current study, we identified dys-regulated lncRNAs in influenza virus-infected human lung epithelial A549 cells using RNA sequencing in A549 cells.

2018-10-12 | GSE121155 | GEO

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Expression data from A549 cell line infected with influenza A virus (IAV) and treated with/without Itaconate

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Proteome wide solubility profiling of Nucleozin treated A549 cells infected with Influenza-A

Project description:A549 WT and Rab11 deleted cell lines were infected with influenza-A and treated with nucleozin. We have evaluated the effect of an antiviral drug, nucleozin, on protein solubility at 13 hpi with influenza-A virus.

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