Gastrointestinal symptoms and pathology in patients with Common variable immunodeficiency

ABSTRACT: Based on the findings of increased IEL in duodenal biopsies in CVID, an overlap with celiac disease has been suggested. In the present study, increased IEL, in particular in the pars descendens of the duodenum, was one of the most frequent histopathological finding. We therefore examined the gene expression profile in pars descendens of duodenum in CVID patients with increased IEL (n=12, IEL mean 34 [range 22-56] IEL/100 EC), CVID with normal levels of IEL (n=8), celiac disease (n=10, Marsh grade 3a or above) and healthy controls (n=17) by gene expression microarray

ORGANISM(S): Homo sapiens

PROVIDER: GSE72625 | GEO | 2015/09/02

SECONDARY ACCESSION(S): PRJNA294507

REPOSITORIES: GEO