Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human KASUMI-1 cells: Control vs Radotinib (RD) 5uM

ABSTRACT: Transcriptional profiling of KASUMI-1 cells comparing between control (DMSO-treated) and radotinib treated Kasumi-1 cells at 48hr

ORGANISM(S): Homo sapiens

PROVIDER: GSE72926 | GEO | 2015/09/11

SECONDARY ACCESSION(S): PRJNA295332

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Human KASUMI-1 cells: Control vs Radotinib (RD) 5uM

Project description:Transcriptional profiling of KASUMI-1 cells comparing between control (DMSO-treated) and radotinib treated Kasumi-1 cells at 48hr one-condition experiment, Control vs RD 5 uM. Biological replicates: 1.

2015-09-11 | E-GEOD-72926 | biostudies-arrayexpress

KASUMI-1ctrl vs KASUMI-1 Saha (Vorinostat; suberoylanilide hydroxamic acid) 6h

Project description:miRNA expression profiling of KASUMI-1 ctrl vs KASUMI-1 treated Saha 5 µM 6h

2017-05-22 | GSE69956 | GEO

Human HepG2 cells: control DMSO vs. K7174-treated

Project description:Transcriptional profiling of human HepG2 cells comparing control DMSO-treated cells with K7174-treated cell

2014-08-01 | GSE48618 | GEO

Expression analysis of Kasumi-1 cells treated with or without FTY720

Project description:The clinical outcomes of M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) are poor. Here we report that FTY720 (Fingolimod), a sphingosine analogue and an FDA approved drug for treatment of multiple sclerosis, showed great antitumorigenic activity against Kasumi-1 cell line, xenograft mouse model and leukemic blasts isolated from AML-M2 with t(8;21) patients. Primary investigation indicated that FTY720 caused cell apoptosis through caspase and protein phosphatase 2A (PP2A) activation. Transcriptomic profiling further revealed that FTY720 treatment could upregulate AML1 target genes and interfere with genes involved in ceramide synthesis. FTY720 treatment led to the elimination of AML1-ETO oncoprotein and caused cell cycle arrest. More importantly, FTY720 treatment resulted in rapid and significant increment of pro-apoptotic ceramide levels, determined by HPLC-ESI-MS/MS (high-performance liquid chromatography-electrospray ionization tandem mass spectrometry) based lipidomic approaches. Additionally, structural simulation model indicated that the directly binding of ceramide to inhibitor 2 of PP2A (I2PP2A) could reactivate PP2A and cause cell death. This study demonstrates, for the first time, that accumulation of ceramide plays a central role in FTY720 induced cell death of AML-M2 with t(8;21). Targeting sphingolipid metabolism by using FTY720 may provide novel insight into drug development for AML-M2 treatment. A six chip study using total RNA recovered from three separate cultures of DMSO-treated Kasumi-1 cells and three separate cultures of FTY720-treated Kasumi-1 cells.Each chip measures the expression level of genes from DMSO-/FTY720-treated Kasumi-1 cells.

2014-04-30 | E-GEOD-55772 | biostudies-arrayexpress

Wildtype (N2) C. elegans: Control vs. 10mM LiCl treated for 48hr at 25oC

Project description:Transcriptional profiling of adult C. elegans comparing control untreated with populations exposed to 10mM LiCl. Populations treated from larval stage L4 for 48hr at 25oC. 10mM LiCl contained in the Nematode Growth Media (NGM) Keywords: Drug treatment

2007-12-01 | GSE8058 | GEO

mRNA expression quantitative Analysis of Kasumi-1 treated with I3 compared with control

Project description:The goals of this study are toevaluate the mRNA expressions of genes in Kasumi-1 cell lines treated with I13

2022-09-16 | GSE193969 | GEO

mRNA expression quantitative Analysis of Kasumi-1 treated with I1 compared with control

Project description:The goals of this study are toevaluate the mRNA expressions of genes in Kasumi-1 cell lines treated with I13

2022-12-31 | GSE193971 | GEO

mRNA expression quantitative Analysis of Kasumi-1 treated with I13 compared with control

Project description:The goals of this study are toevaluate the mRNA expressions of genes in Kasumi-1 cell lines treated with I13

2022-05-05 | GSE193964 | GEO

Human TNBC Cells 48h Treatment with OTSSP167 MELK Inhibitor vs. DMSO Control

Project description:Microarray comparing TNBC cells treated for 48 hours with OTSSp167 MELK Inhibitor and control (DMSO)

2017-05-01 | GSE68652 | GEO

J774.1 mouse macrophage-like cell line: Control vs. IR or TAM or Torin1

Project description:Transcriptional profiling of J774.1 cells comparing control (DMSO treatment) with IR or TAM or Torin1 treated cells.

2022-02-15 | GSE166821 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data