Global transcriptome profiling of the 482N1 mouse metastasis-derived cell line, with or without Arntl2 knockdown

ABSTRACT: In order to determine the role of the transcription factor Arntl2 in regulating metastatic ability and identify Arntl2-dependent transcriptonal targets in metastatic lung adenocarcinoma, we sequenced the mRNA from 3 mouse metastasis cell lines. Each of these cell lines (482N1shLuciferase, 482N1shArntl2#1, and 482N1shArntl2#2) were derived from the same parental cell line, 482N1. 482N1 was derived from a lymph node metastasis of a Kras LSL G12D, p53 flox/flox 129S1/SvlmJ mouse model of metastatic lung adenocarcinoma. A comparison of shLuciferase and shArntl2 cell lines reveals Arntl2-dependent changes in the metastatic transcriptome.

ORGANISM(S): Mus musculus

PROVIDER: GSE72942 | GEO | 2016/02/08

SECONDARY ACCESSION(S): PRJNA295388

REPOSITORIES: GEO