Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Generation of induced pluripotent stem cells from human mesenchymal stem cells of parotid gland origin

ABSTRACT: Transcriptome analysis between PMSCs and PMSC-iPSCs

ORGANISM(S): Homo sapiens

PROVIDER: GSE72984 | GEO | 2015/09/15

SECONDARY ACCESSION(S): PRJNA295537

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Generation of induced pluripotent stem cells from human mesenchymal stem cells of parotid gland origin

Project description:Transcriptome analysis between PMSCs and PMSC-iPSCs We compared the global gene expression between PMSCs and PMSC-iPSCs using the Affymetrix Human U133 gene chip. Array data was processed by Affymetrix Exon Array Computational Tool. No techinical replicates were performed.

2015-09-15 | E-GEOD-72984 | biostudies-arrayexpress

Generation of induced pluripotent stem cells from human mesenchymal stem cells of parotid gland origin.

Project description: Not available

| S-EPMC4846893 | biostudies-literature

Mesenchymal stem/stromal cells from human pluripotent stem cell-derived brain organoid enhance the ex vivo expansion and maintenance of hematopoietic stem/progenitor cells

Project description:We report a novel method for harvesting MSCs from 3D human brain organoids under serum-free culture condition. The stromal cells, derived from both H1-hESCs and human induced pluripotent stem cells (hiPSCs) forebrain organoids, were capable of differentiating into the classical mesenchymal-derived cells (osteoblasts, chondrocytes, and adipocytes). These cells expressed MSC markers, thus named pluripotent stem cell-derived MSCs (pMSCs).To investigate the role of pMSCs, we compared the RNA sequencing of pMSCs ,umbilical cord-MSC,hiPSCs and H1 hESCs.To investigate the function pMSC in the regulation of umbilical cord blood HSPCs, we compared the RNA sequencing of CD34+ cells after co-culturing with and without pMSC and UC-MSCs,respectively.We then performed gene expression profiling analysis using data obtained from RNA-seq of 9 kinds of different cells.

2023-12-13 | GSE220781 | GEO

Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis

Project description:We performed transcriptomic studies comparing phenotypically defined PMSCs (PDGFRa/CD34/CD9high:CD200low) to HSCs (Vitamin-A fluorescent) of high purity, using bulk RNAseq. We further extended bulk RNAseq analyses of the two cell populations to myofibroblasts derived from both cell types in culture, including an early and late stage of differentiation for PMSC-MFs. Comparative analyses of gene expression indicated that 100 genes in PMSCs and 112 genes in HSCs, i) were overexpressed according to both scRNAseq and bulk RNAseq analyses, and ii) remained differentially expressed in these cells throughout their myofibroblastic differentiation. We selected the most differentially expressed of these genes, to build a multigene expression signature of PMSCs/PMSC-MFs (7 genes) and of HSCs/HSC-MFs (6 genes).

2021-03-31 | GSE164037 | GEO

Mesenchymal stromal cell transcriptome study

Project description:Transcriptomes of mesenchymal stromal cells from bone marrow (bmMSC) were compared to MSC from term placenta (pMSC). Cells were expanded under GMP-compliant conditions. The transcriptome was explored to compare the regenerative potential of bmMSCs and pMSCs in a pre-clinical and eventually in a clinical context

2016-11-23 | GSE90149 | GEO

Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis

Project description:Based on the identification of a transcriptomic signature, including Slit2, characterizing portal mesenchymal stem cells (PMSC) and derived myofibroblast (MF), we examined the gene expression profile of in liver tissue derived from multiple human liver disorders, including primary sclerosing cholangitis (PSC) (n=12), non-alcoholic steatohepatitis (NASH) (n=7) and other liver diseases (i.e., primary biliary cholangitis, autoimmune hepatitis, alcoholic liver disease and haemochromatosis) (n=8) and compared them to healthy controls (tumor free tissue from livers with metastasis from colorectal cancer) (n=5). We found that SLIT2 was overexpressed in the liver of patients with NASH, PSC and other chronic liver diseases. We also examined the microarray data of the human liver tissue samples for the transcriptomic signatures and found that in the different types of liver diseases the gene signature of PMSCs/PMSC-MFs was increased compared to normal liver, and correlated with the expression of ACTA2, COL1A1 and vWF.

2020-10-21 | GSE159676 | GEO

Cytogenomic Abnormalities in 19 Cases of Salivary Gland Tumors of Parotid Gland Origin.

Project description: Not available

| S-EPMC7725583 | biostudies-literature

Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity.

Project description: Not available

| S-EPMC4627247 | biostudies-literature

Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Show Comparable Functionality to Their Autologous Origin.

Project description: Not available

| S-EPMC7823915 | biostudies-literature

Scalable Generation of Mesenchymal Stem Cells and Adipocytes from Human Pluripotent Stem Cells.

Project description: Not available