Affymetrix SNP array data for myelodysplastic syndromes (MDS) samples

ABSTRACT: The progressive mechanism of myelodysplastic syndrome (MDS) remains unknown. We report that ROBO1 and ROBO2 are identified as novel progression-related somatic mutations using whole-exome and targeted sequencing in six of 16 (37.5%) paired MDS patients undergoing disease progression. To investigated the effect of ROBO1 or ROBO2 on ROBO1/2 CN number and LOH, we employed a Cytosan 750K chip to analyze the copy-number variations (CNVs) and loss of heterogeneity (LOH) in MDS patients with ROBO1&2 mutations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73005 | GEO | 2015/09/15

SECONDARY ACCESSION(S): PRJNA295958

REPOSITORIES: GEO