Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500 (Cryptococcus neoformans)
SUBMITTER: Christina M. Homer
PROVIDER: GSE73203 | GEO | 2016-06-08
SECONDARY ACCESSION(S): PRJNA296366
REPOSITORIES: GEO
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GSE73203_RAW.tar | Raw | |||
filelist.txt | Txt |
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Homer Christina M CM Summers Diana K DK Goranov Alexi I AI Clarke Starlynn C SC Wiesner Darin L DL Diedrich Jolene K JK Moresco James J JJ Toffaletti Dena D Upadhya Rajendra R Caradonna Ippolito I Petnic Sarah S Pessino Veronica V Cuomo Christina A CA Lodge Jennifer K JK Perfect John J Yates John R JR Nielsen Kirsten K Craik Charles S CS Madhani Hiten D HD
Cell host & microbe 20160519 6
Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling molecules impact population function and gene expression. QS-like phenomena have been reported in eukaryotes with largely unknown contributing molecules, functions, and mechanisms. We identify Qsp1, a secreted peptide, as a central signaling molecule that regulates virulence in the fungal pathogen Cryptococcus neoformans. QSP1 is a direct target of three transcription factors required for virulence, and qsp1Δ ...[more]