Genomics

Dataset Information

0

The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients


ABSTRACT: The goal of this study was to assess whether the presence of HLA-B*35 contributes to activation of ER stress/UPR and inflammation in lcSScPAH PBMC. HLA-B*35 is associated with increased risk of developing PAH in lcSSc patietns. Also we previously reported that HLA-B*35 induces ECs dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Our study demonstrates that HLA-B*35 contributes to the dysregulated expression of selected ER stress, inflammation and proliferation related genes in lcSSc patient PBMCs, as well as healthy individuals, thus supporting a pathogenic role of HLA-B*35 as a risk factor for developing PAH in SSc patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73355 | GEO | 2016/11/02

SECONDARY ACCESSION(S): PRJNA296782

REPOSITORIES: GEO

Similar Datasets

2010-03-01 | GSE20055 | GEO
2015-05-12 | GSE68718 | GEO
2013-03-25 | BIOMD0000000446 | BioModels
| E-GEOD-68718 | biostudies-arrayexpress
2022-12-19 | GSE221290 | GEO
2018-10-31 | GSE99763 | GEO
2021-02-17 | GSE146841 | GEO
2021-12-20 | GSE146723 | GEO
| E-GEOD-10091 | biostudies-arrayexpress
2024-01-17 | GSE225569 | GEO