Transcriptomics,Genomics

Dataset Information

17

Gene array data of tumour draining lymph node fibroblastic reticular cells (FRCs)


ABSTRACT: Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical structural support and regulate immunity, tolerance and transport properties of LNs. In many tumors, LN metastasis is predictive of poor prognosis, however, stromal contribution to the evolving microenvironment of tumor draining LNs (TDLN) remains poorly understood. Here we present comparative transcriptional data of resting and TDLN FRCs after different time points of tumor drainage. FRCs were isolated from lymph nodes and FACS sorted based on the expression of CD45-, CD31- and PDPN+ Overall design: FRCs were pooled per animal of 2 brachial LNs and gene array analysis was performed on triplicates

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

SUBMITTER: Angela Riedel   

PROVIDER: GSE73728 | GEO | 2016-07-11

SECONDARY ACCESSION(S): PRJNA297773

REPOSITORIES: GEO

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Publications

Tumor-induced stromal reprogramming drives lymph node transformation.

Riedel Angela A   Shorthouse David D   Haas Lisa L   Hall Benjamin A BA   Shields Jacqueline J  

Nature immunology 20160711 9


Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical structural support and regulate immunity, tolerance and the transport properties of LNs. For many tumors, metastasis to the LNs is predictive of poor prognosis. However, the stromal contribution to the evolving microenvironment of tumor-draining LNs (TDLNs) remains poorly understood. Here we found that FRCs specifically of TDLNs proliferated in response to tumor-derived cues and that the network the  ...[more]

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