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FOXO regulates RNA interference in Drosophila and protects from RNA virus infection

ABSTRACT: Determination of dFOXO binding sites genomewide identified RNAi genes as direct targets

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE73827 | GEO | 2015/10/08

SECONDARY ACCESSION(S): PRJNA298077

REPOSITORIES: GEO

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FOXO regulates RNA interference in Drosophila and protects from RNA virus infection.

Project description: Not available

| S-EPMC4664361 | biostudies-literature

Titered FOXO overexpression maintains cardiac proteostasis and ameliorates age-associated functional decline

Project description:Heart performance declines with age. Reduced protein quality control (PQC) due to decreased function of the ubiquitin/proteasome system (UPS), autophagy, and/or chaperone-mediated protein refolding is a likely contributor to age-associated cardiac performance decline. The transcription factor FOXO participates in the regulation of genes involved PQC and a host of other processes. Here, the effect of cardiac-restricted dFOXO overexpression was investigated in Drosophila, a genetically pliable and rapidly aging model. Modest dFOXO overexpression in the heart was protective, ameliorating functional decline with age. Increased expression of genes associated predominantly with UPS relative to other PQC components accompanied dFOXO-mediated cardioprotection, which was corroborated by a significant decrease in ubiquitinated myocardial proteins. In agreement, knockdown of upregulated UPS components seemingly induced premature aging. Despite these findings, excessive dFOXO overexpression or knockdown proved detrimental to heart function and overall organismal development. This study highlights Drosophila as a model of cardiac aging and FOXO as a tightly-regulated mediator of proteostasis and heart performance over time.

2016-07-01 | GSE73205 | GEO

Age-dependent changes in transcription factor FOXO targeting in Drosophila melanogaster

Project description:FOXO transcription factors control numerous pathways involving metabolism, stress response, and longevity. Although direct targets of FOXO have been reported in various long-lived mutants and under stress conditions, no studies have investigated how normal aging impacts the cellular activity of FOXO. In this study, we compared genome wide dFOXO-bound sites in young and aged wild-type flies kept under normal feeding conditions to evaluate the dynamics of FOXO gene targeting during aging. Our results provide a new insight into FOXO chromatin targeting under a normal aging model and highlight the diverse regulatory mechanisms for FOXO transcriptional activity that are currently less understood.

2019-04-25 | GSE121102 | GEO

Titered FOXO overexpression maintains cardiac proteostasis and ameliorates age-associated functional decline

2016-07-01 | E-GEOD-73205 | biostudies-arrayexpress

RNA interference modulates replication of dengue virus in Drosophila melanogaster cells.

Project description: Not available

| S-EPMC2874549 | biostudies-literature

Genome-wide analysis of dFOXO binding sites in Drosophila

Project description:To understand how reduced insulin/IGF-1 signaling extends Drosophila lifespan through its downstream transcription factor dFOXO. We conducted ChIP analysis with a dFOXO antibody followed by Illumina high-throughput sequencing from chico heterozygous mutants, which are long-lived and normal sized, and from adult flies with ablated insulin producing cells (IPCs), which are also long-lived. dFOXO bound at promoters of 273 genes common among these genotypes, thus potentially enriching for shared factors in control of aging.

2013-09-20 | GSE44686 | GEO

Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.

Project description: Not available

| S-EPMC3538939 | biostudies-literature

Low FoxO expression in Drosophila somatosensory neurons protects dendrite growth under nutrient restriction.

Project description: Not available

| S-EPMC7308081 | biostudies-literature

Transcriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster

Project description:Transcriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster. The experiment was performed to examine which parts of the transcriptional response to a reduction in insulin signalling in an adult female fly depend on the presence of the dfoxo transcription factor. Whole fly transcriptome was determined with flies over-expressing a dominant negative form of the insulin receptor, or the wild-type fly, in presence or absence of dfoxo.

2011-06-18 | E-TABM-757 | biostudies-arrayexpress

Genome-wide analysis of dFOXO binding sites in Drosophila

2013-09-20 | E-GEOD-44686 | biostudies-arrayexpress

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