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Newly constructed network models of different WNT signaling cascades applied to breast cancer expression data

ABSTRACT: RNA-Seq profiling of MCF-7 and MDA-MB-231. We profiled RNA expression in the estrogen-receptor-positive (ER+) MCF-7 and the triple-negative MDA-MB-231 breast cancer cells. The objective was to find genes differentially expressed between these cell lines as potential drivers of invasiveness of the triple-negative MDA-MB-231. We further utilized the identified differential genes to validate expression-responsive module of non-canonical Wnt signaling pathway.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73857 | GEO | 2016/01/21

SECONDARY ACCESSION(S): PRJNA298248

REPOSITORIES: GEO

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