Dataset Information


Repression of stress-induced LINE-1 expression protects cancer cell populations from lethal drug-exposures [ChIP-Seq]

ABSTRACT: Merkel cell carcinoma is a skin cancer associated with the Merkel cell polyomavirus (MCPyV) which is found integrated in the genome of the tumor cells. Here 4 MCPyV-positive tumor cell lines (AlDo, LoKe, BroLi and WoWe) were analyzed by comparative gernomic hybridization to define further genetic alterations. Corresponding peripheral blood lymphocytes (PBL) in case of AlDo and LoKe, purified T cells in case of BroLi and Tumor-derived but virus-negative cells of unknown origin (WoWe1) in case of WoWe served as controls. Overall design: Comparative genomic hybridization to define amplifications and deletions in the MCC genome.

INSTRUMENT(S): [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array

SUBMITTER: Claus Juergen Scholz 

PROVIDER: GSE73879 | GEO | 2016-06-21



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RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.

Hesbacher Sonja S   Pfitzer Lisa L   Wiedorfer Katharina K   Angermeyer Sabrina S   Borst Andreas A   Haferkamp Sebastian S   Scholz Claus-Jürgen CJ   Wobser Marion M   Schrama David D   Houben Roland R  

Oncotarget 20160501 22

The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing tumor suppressive properties. Indeed, the PPs jointly control the G1/S transition mainly by inhibiting E2F transcription factors. Notably, several viral oncoproteins are capable of binding and inhibiting PPs. Merkel cell polyomavirus (MCPyV) is considered as etiological factor for Merkel cell carcinoma (MCC) with expression of the viral Large T antigen (LT) harboring an intact PP binding domain being r  ...[more]

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