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Quadruplex ligand Tetra-Pt(bpy) Induces the Death of Human ALT Cancer Cells by Inhibiting Homologue Recombination-Mediated Telomere Elongation

ABSTRACT: The RNA-seq results reveal Tetra-Pt(bpy) has no effect on gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74029 | GEO | 2015/10/15

SECONDARY ACCESSION(S): PRJNA298773

REPOSITORIES: GEO

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Pt-ttpy, a G-quadruplex binding platinum complex, induces telomere dysfunction and G-rich regions DNA damage

Project description:Pt-ttpy (tolyl terpyridin-Pt complex) covalently binds to G-quadruplex (G4) structures in vitro and to telomeres in cellulo via its Pt moiety. Here, we identified its targets in the human genome, in comparison to Pt-tpy, its derivative without G4 affinity, and cisplatin. Pt-ttpy, but not Pt-tpy, induces the release of the shelterin protein TRF2 from telomeres concomitantly to the formation of DNA damage foci at telomeres but also at other chromosomal locations. -H2AX chromatin immunoprecipitation (ChIP-seq) after treatment with Pt-ttpy or cisplatin revealed accumulation in G- and A-rich tandemly repeated sequences, but not particularly in potential G4 forming sequences. Collectively, Pt-ttpy presents dual targeting efficiency on DNA, by inducing telomere dysfunction and genomic DNA damage at specific loci.

2021-05-04 | GSE171450 | GEO

Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells.

Project description: Not available

| S-EPMC3264516 | biostudies-literature

Fusarium sp. PT strain:PT

Project description:Fusarium sp. isolate PT

| PRJNA737353 | ENA

ChIP-chip from Drosophila egg chambers using antibody recognizing tetra-acetylated histone H4

Project description:Chromatin immunoprecipitation of tetra-acetylated histone H4 followed by hybridization to genome-wide tiling microarrays demonstrated that tetra-acetylated H4 is enriched at the two chorion Drosophila amplicons in follicle cells (DAFC) as well as other non-amplified loci Comparison of tetra-acetylated H4 ChIP sample compared to input DNA for two different Drosophila strains

2011-05-27 | E-GEOD-29520 | biostudies-arrayexpress

ChIP-chip from Drosophila egg chambers using antibody recognizing tetra-acetylated histone H4

2011-05-27 | GSE29520 | GEO

Mapping PT modifications in bacteria

Project description:One microbial organism always contains multiple DNA modification systems as defense strategies or epigenetic controls. Here, we describe crosstalk between two distinct DNA modifications with different target sequence motif: DNA phosphorothioation (PT, GPSAAC/GPSTTC by DndACDE proteins) and N6-methyl-adenine methylation (m6A, G6mATC by Dam protein). By using a newly developed DNA modification sequencing method PT nick-seq, we found that half of PT modifications change from GAAC/GTTC to GATC sites after bacteria have lost Dam.

2020-05-21 | GSE135910 | GEO

Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination.

Project description: Not available

| S-EPMC2747187 | biostudies-literature

Tetra-Amelia with lung aplasia phenotype

Project description:Tetra-Amelia with lung aplasia phenotype

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Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair.

Project description: Not available

| S-EPMC8724847 | biostudies-literature

PT-modified B12 probe and Non-PT-modified B34 probe pull-down with Salmonella enterica serovar Cerro 87 cell lysate

Project description:To capture proteins that exhibit differential binding with PT- and non-PT-modified DNA in vivo, we performed pull-down assays using biotinylated DNA probes and the cell lysate of S. enterica serovar Cerro 87 that contains the dndBCDE-dndFGH module. For these experiments, we used two 30 bp DNA probes, B12 and B34, which share the same DNA sequences but possess PT-modified 5’-GPSAAC-3’/5’-GPSTTC-3’ and non-PT-modified 5’-GAAC-3’/5’-GTTC-3’ motifs, respectively.

2022-02-26 | PXD031869 | Pride

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