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Genome-wide analysis of gene expression after AML1-ETO and Ezh1 knock down in leukemia

ABSTRACT: The chimeric protein AML1-ETO is subjected to an array of posttranslational modifications that crucially regulate its functions. Enhancer of zeste homolog 1 (Ezh1) regulates gene expression through its histone methyltransferase activity. In this study, we test the impact of Ezh1 on AML1-ETO regulating target gene expression. Results provide important information of the response of Ezh1 knock down, AML1-ETO knock down or both.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74237 | GEO | 2019/10/16

REPOSITORIES: GEO

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