Intragraft gene expression profile associated with the induction of tolerance

ABSTRACT: Xenotransplantation holds the promise of providing an unlimited supply of donor organs for terminal patients with organ failure. The gal carbohydrate results in rejection of wild type pig grafts, however, chimerism established by expression of the GalT gene prior to transplantation in GalT knockout mice results in tolerance to Gal+ heart grafts. We used microarrays in order to further understand the early events that occur within grafts that demonstrate tolerance. Keywords: transplntation tolerance

ORGANISM(S): Mus musculus

PROVIDER: GSE7424 | GEO | 2007/04/03

SECONDARY ACCESSION(S): PRJNA97859

REPOSITORIES: GEO