Positional proteomics reveals differences in N-terminal proteoform stability

ABSTRACT: To understand the impact of alternative translation initiation on a proteome, we performed the first study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes. Overall, we monitored the stability of 1,941 human N-terminal proteoforms, including 147 N-terminal proteoform pairs that originate from alternative translation initiation, alternative splicing or incomplete processing of the initiator methionine.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74279 | GEO | 2015/10/23

REPOSITORIES: GEO