IL-22 regulation of functional gene expression in salivary gland cells

ABSTRACT: Microarray analysis using the HumanHT-12 v4 Expression BeadChip was utilized to determine the biological function of IL-22. The data indicate an extensive effect of IL-22 on many major molecular functions including activation of antimicrobial genes and downregulation of immune-associated pathways. Functional studies performed in-vitro using human salivary gland cells treated with IL-22 indicated a direct effect of IL-22 on cell cycling, specifically reducing cellular proliferation at the G2-M phase by activation of STAT3.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74389 | GEO | 2015/10/27

SECONDARY ACCESSION(S): PRJNA300262

REPOSITORIES: GEO