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MicroRNAs are involved in the regulation of ovary development in the pathogenic blood fluke Schistosoma japonicum

ABSTRACT: We report on the small RNA profiles of Schistosoma japonicum (S. japonicum) miRNAs using small RNA deep sequencing in the key stages of male-female pairing, gametogenesis, and egg production.

ORGANISM(S): Schistosoma japonicum

PROVIDER: GSE74654 | GEO | 2016/01/07

SECONDARY ACCESSION(S): PRJNA301073

REPOSITORIES: GEO

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MicroRNAs are involved in the regulation of ovary development in the pathogenic blood fluke Schistosoma japonicum

Project description:We report on the small RNA profiles of Schistosoma japonicum (S. japonicum) miRNAs using small RNA deep sequencing in the key stages of male-female pairing, gametogenesis, and egg production. Examination of different miRNAs between males and females in Schistosoma japonicum

2016-01-07 | E-GEOD-74654 | biostudies-arrayexpress

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Gene expression profiles of Schistosoma japonicum in four developmental stages

Project description:In the complex lifecycle of schistosomes, four developmental stages are closely associated with their definitive hosts: cercaria (infective stage), schistosomula and adult worm (parasitic stages), egg (pathogenic- and pathophoresis-stage). We have examined the gene expression profiles of Schistosoma japonicum in the four developmental stages. Genes with different expression patterns were identified and the information obtained will help indentify new anti-schistosomal intervention targets in the future.

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Schistosoma japonicum differentially expressed gene at different development stage

Project description:Analysis of differentially expressed gene of different parasite stage helps to determine which genes are likely to be the key players in transition through a developmental stage, thus help to further understand schistosome biology and host-parasite relationship, facilitate the discovery of novel gene products than could represent targets for the development of new drugs and vaccines to control schitosomiasis.Samples were analyzed at cercariae, egg and adult worm stage. Keywords = Schistosoma japonicum Keywords = different development stage Keywords = differentially expressed gene Keywords: time-course

2009-03-10 | GSE2474 | GEO

Developmental gene expression profiles of the human pathogen Schistosoma japonicum

Project description:The life cycle of schistosomes is complex, being characterised by a series of distinct parasitic and free-living phases involving an invertebrate snail host, water and a mammalian host. A custom designed oligonucleotide microarray was utilized to profile developmental gene expression in the Asian blood fluke, Schistosoma japonicum during these parasitic and free-living transitions. Total RNAs were isolated from lung schistosomula, juvenile females and males (paired but little or no egg production), adult males and females (paired with full scale egg production), eggs, miracidia, sporocysts and cercariae. We focused on the three distinct environmental phases of the lifecycle - aquatic/snail (eggs, miracidia, sporocysts, cercariae), juvenile (lung schistosomula and paired pre-egg laying adults) and adult (paired males and females, both examined separately) stages.

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Mice liver RNA-Seq during Schistosoma japonicum infection

Project description:The gogal of this study is to use RNA-Seq to systematically investigate the dynamics of the liver transcriptome over Schistosoma japonicum infection.

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MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection

Project description:Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanisms that underlie the hepatic pathogenesis induced by schistosomal egg deposition have not yet been well-defined. Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected BALB/c mice at day 15, 30, and 45 post infection (pi) with that from uninfected mice as controls. Meanwhile, microRNA expression profiles from the same samples were decoded by parallel solexa sequencing. Gene expression alternation associated with liver damage was observed even at early stage of infection (e.g., pi 15), which became more magnificent onset of egg deposition within the liver tissue. Up-regulated genes were dominantly associated with inflammatory infiltration of liver during S. japonicum infection, whereas down-regulated genes primarily led to the hepatic functional disorders. More than 130 miRNAs were differentially expressed during S. japonicum infection, and dynamic miRNA-gene co-expression network has been constructed during the development of hepatic pathology.

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