Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data of Langerhans cells purified from Il34+/LacZ and Il34LacZ/LacZ mice after UV treatment

ABSTRACT: We examined the impact of IL-34 on repopulation of Langerhans cells after inflammation

ORGANISM(S): Mus musculus

PROVIDER: GSE74686 | GEO | 2015/11/04

SECONDARY ACCESSION(S): PRJNA301155

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data of Langerhans cells purified from Il34+/LacZ and Il34LacZ/LacZ mice after UV treatment

Project description:We examined the impact of IL-34 on repopulation of Langerhans cells after inflammation Langerhans cells were FACS-purified from Il34+/LacZ and Il34LacZ/LacZ mice after UV treatment

2015-11-04 | E-GEOD-74686 | biostudies-arrayexpress

Long-term repopulation of Langerhans cell network following immune injury is inefficient and solely dependent upon influx of monocyte precursors

Project description:RNAseq gene expression following the repopulation of the langerhans cell network in immune deficient irradiated mice after ectopic injection of donor bone marrow cells

2019-06-14 | GSE130257 | GEO

Langerhans cell RNAseq

Project description:Langerhans cell RNAseq

| PRJNA587425 | ENA

Langerhans cell RNAseq

Project description:CD45.1 bone marrow cells were transplanted into irradiated CD45.2 host to generate bone marrow chimera mice. Skin langerhans cells and other dendritic cell subsets were sorted from chimera mice and sequenced.

2021-03-22 | GSE139877 | GEO

Notch is active in Langerhans Cell Histiocytosis and confers pathognomonic features on dendritic cells.

Project description:Langerhans cell histiocytosis (LCH) is a disease characterized by the accumulation of eponymous CD1a+ Langerin+ Langerhans-cell (LC)-like dendritic cells (DC) of largely unknown origin. Here we have performed comparative transcriptome analysis of highly purified CD207+/CD1a+ Langerhans cell histiocytosis (LCH) cells derived from different locations and disease courses and three major human dendritic cell lineages: epidermal Langerhans cells, myeloid dendritic cells (mDC1) and plasmacytoid dendritic cells (pDC) in order to investigate the relationship between LCH cells and naturally occurring dendritic cells. Data obtained indicate that LCH cells form a distinct DC entity. Furthermore, we have identified transcripts that are uniquely expressed by LCH cells in comparison to LC, mDC1, and pDC, and induce LCH-specific features in human DC. Primary cells were isolated from peripheral blood (mDC1 and pDC), skin (epidermal Langerhans cells) and CD207+/CD1a+ Langerhans cell histiocytosis (LCH) cells derived from different locations. RNA was isolated from these cells ex vivo.

2012-10-24 | E-GEOD-35340 | biostudies-arrayexpress

Langerhans dendritic cell differentiation and TGFbeta

Project description:To identify genes with a potential role in Langerhans dendritic cell differentiation, progenitor cells from human cord blood were analyzed by Affymetrix GeneChip U133Plus 2.0 microarray profiling

2016-12-31 | GSE31318 | GEO

RNA-seq analysis of αPD-1 treatment outcomes in IL-34 expressing or not expressing CT26 cell line

Project description:Interleukin-34 (IL-34) is an alternative ligand to colony-stimulating factor-1 (CSF-1) for the CSF-1 receptor that acts as a key regulator of monocyte/macrophage lineage. In this study, we show that cancer cells-derived IL-34 mediates resistance to immune checkpoint blockade regardless of CSF-1 existence. In a therapeutic study of a programmed death-1 and cytotoxic T-lymphocyte-associated antigen-4 blocking monoclonal antibody, the expression of IL-34 in tumors was accompanied with limited benefits compared to IL-34 non-expressing tumors in various murine cancer models. Consistent with its immunosuppressive characteristics, the expression of IL-34 in tumors correlates with decreased frequencies of cellular (such as CD8+ and CD4+ T cells) and molecular (including various cytokines and chemokines) effectors at the tumor microenvironment. In addition, IL-34 blockade expands the M1-macrophage population. Then, a neutralizing antibody against IL-34 helped to reverse these effects and improved the therapeutic effects of the immune checkpoint blockade in combinatorial therapeutic models, including a patient-derived xenograft model of primary lung adenocarcinoma. Collectively, we revealed that tumor-derived IL-34 inhibits the efficacy of immune checkpoint blockade and proposed the utility of IL-34 blockade as a new strategy for cancer therapy.

2020-09-30 | GSE157602 | GEO

Comparison of skin and in vitro differentiated human Langerhans cells

Project description:Langerhans cells were prepared from skin or derived from cord blood CD34+ cells

2021-03-04 | GSE168167 | GEO

Notch is active in Langerhans Cell Histiocytosis and confers pathognomonic features on dendritic cells.

2012-10-24 | GSE35340 | GEO

Trancriptomics of primary human monocytes, Langerhans cells (LC), and monocyte-derived Langerhans cells (moLC)

Project description:Trancriptomics of primary human monocytes, Langerhans cells (LC), and monocyte-derived Langerhans cells (moLC)

| PRJNA591877 | ENA