Transcriptomics,Genomics

Dataset Information

30

Mouse Brain Voxelation, Voxels


ABSTRACT: Transcriptional profiling of mouse brain voxels from a single coronal slice of the mouse brain comparing each voxel to whole mouse brain RNA. Goal was to determine the gene expression profiles for the mouse genome in a coronal slice of the mouse brain. Keywords: Genetic modification Overall design: Two-condition experiment, Voxel vs. Whole Brain RNA. Biological replicates: 3 independent datasets from mouse brains, independently harvested. One voxel replicate per array.

INSTRUMENT(S): VMSR Mus 20K version 2

SUBMITTER: Mark H. Chin  

PROVIDER: GSE7480 | GEO | 2007-07-12

SECONDARY ACCESSION(S): PRJNA100291

REPOSITORIES: GEO

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Publications

A genome-scale map of expression for a mouse brain section obtained using voxelation.

Chin Mark H MH   Geng Alex B AB   Khan Arshad H AH   Qian Wei-Jun WJ   Petyuk Vladislav A VA   Boline Jyl J   Levy Shawn S   Toga Arthur W AW   Smith Richard D RD   Leahy Richard M RM   Smith Desmond J DJ  

Physiological genomics 20070515 3


Gene expression signatures in the mammalian brain hold the key to understanding neural development and neurological diseases. We have reconstructed two-dimensional images of gene expression for 20,000 genes in a coronal slice of the mouse brain at the level of the striatum by using microarrays in combination with voxelation at a resolution of 1 mm3. Good reliability of the microarray results were confirmed using multiple replicates, subsequent quantitative RT-PCR voxelation, mass spectrometry vo  ...[more]

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