Transcriptomics

Dataset Information

37

Microarray analysis of aortic tissue from different rat hypertensive models


ABSTRACT: To determine if there exists a consistent gene signature associated with vascular hypertrophy among different rat hypertensive models: treated and untreated Wistar Kyoto (WKY) rats and treated and untreated Spontaneous Hypertensive Rat (SHR) rats. Keywords: strain comparison, treatment vs control Overall design: Two strains of rat were studies: WKY which are normotensive and SHR which are hypertensive. Aortic tissue was taken from 6 untreated WKY rats and 6 WKY rats treated with angiotensin. Aortic tissue was taken from 6 untreated SHR rats, 6 treated with nifedipine for two weeks and 5 treated with nifedipine for two weeks and then washed out for three weeks. There was a total of 29 samples. A pool of RNA from 6 untreated WKY rats was used as a reference. Hybridizations were performed in duplicate with a dye-flip and always with the reference as the second color.

INSTRUMENT(S): Agilent-011868 Rat Oligo Microarray G4130A (Feature Number version)

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Lynn M Amon  

PROVIDER: GSE7483 | GEO | 2007-04-11

SECONDARY ACCESSION(S): PRJNA100297

REPOSITORIES: GEO

Similar Datasets

2008-06-15 | E-GEOD-7483 | ArrayExpress
2007-11-28 | GSE8051 | GEO
2010-06-05 | E-GEOD-1932 | ArrayExpress
2015-07-03 | E-GEOD-41453 | ArrayExpress
2014-01-24 | E-GEOD-41452 | ArrayExpress
2013-04-16 | E-GEOD-31457 | ArrayExpress
| GSE53361 | GEO
| GSE92669 | GEO
2008-06-15 | E-GEOD-8051 | ArrayExpress
| GSE53363 | GEO