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Whole-genome effects of elaidic and oleic acids

ABSTRACT: Trans fatty acids (tFAs) may have deleterious, long-term transcriptional effects. To explore that issue, we assessed the effects of the tFA elaidic acid and its cis isomer oleic acid on transcription and, in parallel, on DNA methylation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74874 | GEO | 2015/11/11

SECONDARY ACCESSION(S): PRJNA301707

REPOSITORIES: GEO

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Whole-genome effects of elaidic and oleic acids

Project description:Trans fatty acids (tFAs) may have deleterious, long-term transcriptional effects. To explore that issue, we assessed the effects of the tFA elaidic acid and its cis isomer oleic acid on transcription and, in parallel, on DNA methylation. Human THP-1 monocytes were stimulated with 50 microM of either fatty acid for 24 h, in triplicate.

2015-11-11 | E-GEOD-74874 | biostudies-arrayexpress

Brassica napus high oleic acid vs. low oleic acid

Project description:Compared to ordinary rapeseed, high-oleic acid rapeseed has higher levels of monounsaturated fatty acids and lower levels of saturated fatty acid and polyunsaturated fatty acids, and thus is of high nutritional and health value. In addition, high-oleic acid rapeseed oil imparts cardiovascular protective effects. Based on these properties, high-oleic acid oil crops have been extensively investigated and cultivated. In this study, we employed a microarray analysis with high oleic acid line and low oleic acid line from the developing seeds (27 days after flowering) of Brassica napus.

2018-09-20 | GSE120223 | GEO

Brassica napus high oleic acid vs. low oleic acid

Project description:Brassica napus high oleic acid vs. low oleic acid

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LX2 cell line treated with or without BTC, and with or without fatty acids (Oleic acid and Omega3), and subsequent gene expression

Project description:LX2 cells treated with or without BTC and with or without oleic acid or DHA

2022-10-13 | GSE215223 | GEO

S. aureus gene expression following growth in media containing oleic acid

Project description:S. aureus response to exogenous fatty acid (oleic acid) Gene expression profiles were generated by microarray analysis of S. aureus cells grown in media without or with oleic aicd Comparison of expression profiles after growth of S. aureus in exogenous fatty acid S. aureus was grown in media with and without oleic acid to an OD600nm of 0.5, and RNA was extracted to look at the gobal gene expression.

2012-12-21 | E-GEOD-36231 | biostudies-arrayexpress

S. aureus gene expression following growth in media containing oleic acid

2012-12-21 | GSE36231 | GEO

Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury

Project description:Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis elegans, and mice, we found that ferroptosis occurs in the context of iron-overload-mediated damage. Exogenous oleic acid protected against iron-overload-toxicity in cell culture and Caenorhabditis elegans by suppressing ferroptosis. In mice, oleic acid protected against FAC-induced liver lipid peroxidation and damage. Oleic acid changed the cellular lipid composition, characterized by decreased levels of polyunsaturated fatty acyl phospholipids and decreased levels of ether-linked phospholipids. The protective effect of oleic acid in cells was attenuated by GW6471 (a PPAR- antagonist), as well as in Caenorhabditis elegans lacking the nuclear hormone receptor NHR-49 (a PPAR- functional homologue). These results highlight ferroptosis as a driver of iron-overload-mediated damage, which is inhibited by oleic acid. This monounsaturated fatty acid represents a potential therapeutic approach to mitigating organ damage in iron overload individuals.

2023-10-02 | GSE243891 | GEO

Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions

Project description:Comparing the transcriptomic program induced by oleic acid to that of the pro-inflammatory arachidonic acid, we find that Tregs sorted from peripheral blood and adipose of healthy donors transcriptomically resemble the oleic acid in vitro treated Tregs, whereas Tregs obtained from the adipose tissue of relapsing-remitting MS patients more closely resemble an arachidonic acid profile

2020-11-17 | GSE152543 | GEO

Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions (bulk RNA)

2020-11-17 | GSE151586 | GEO

Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide mediate signaling in plant defense.

Project description:Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide- mediate signaling in plant defense. Nitric Oxide, Oleic acid, Salicylic acid, Arabidopsis, Defense

2012-08-01 | GSE36797 | GEO

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