Genomics

Dataset Information

45

Differential expression of RNAs in E9 tuft rostrums with NTDs


ABSTRACT: Purpose: Identify genes and pathways affected in tuft embryos with NTDs Results: Expression of genes associated with neural tube closure and components of non-canonical WNT signaling/PCP pathways were affected Conclusions: TET1 regulates genes associated with neural tube closure Overall design: RNA pooled from the rostrums of E9 (18-22 somites) tuft/tuft embryos with NTD compared with respective wildtype background strain

INSTRUMENT(S): Ion Torrent Proton (Mus musculus)

SUBMITTER: Keith S Fong  

PROVIDER: GSE75001 | GEO | 2016-05-04

SECONDARY ACCESSION(S): PRJNA302161

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE75001_Tuft_count.txt.gz Txt
GSE75001_WT_count.txt.gz Txt
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Publications

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

Fong Keith S K KS   Hufnagel Robert B RB   Khadka Vedbar S VS   Corley Michael J MJ   Maunakea Alika K AK   Fogelgren Ben B   Ahmed Zubair M ZM   Lozanoff Scott S  

Disease models & mechanisms 20160317 5


Genetic variations affecting neural tube closure along the head result in malformations of the face and brain. Neural tube defects (NTDs) are among the most common birth defects in humans. We previously reported a mouse mutant called tuft that arose spontaneously in our wild-type 3H1 colony. Adult tuft mice present midline craniofacial malformations with or without an anterior cephalocele. In addition, affected embryos presented neural tube closure defects resulting in insufficient closure of th  ...[more]

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