Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [human cell line ChIP-seq]

ABSTRACT: We report the distribution of H3K27Ac histone marks in multiple human melanoma cell lines with the aim of identifying super-enhancer regions and regions of interest. Also performed ChipSeq for H3K4Me1 to identify active enhancers in a representative human melanoma cell line, A375.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75352 | GEO | 2016/02/01

SECONDARY ACCESSION(S): PRJNA304004

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [zebrafish ChIP-seq]

Project description:We report the distribution of H3K27Ac histone marks in a zebrafish melanoma cell line and a zebrafish primary melanoma tumor with the aim of identifying super-enhancer regions and regions of interest. We also report sox10 ChIP-Seq on the same zebrafish melanoma cell line.

2016-02-01 | GSE75353 | GEO

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [ATAC-Seq]

Project description:We report the locations of accessible/open chromatin as assayed by ATAC-Seq on two zebrafish melanoma cell lines, zcrest 1 and zcrest 2.

2016-02-01 | GSE75351 | GEO

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.

Project description: Not available

| S-EPMC4868069 | biostudies-literature

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [human cell line RNA-seq]

Project description:We report gene expression data for human melanoma cell lines using RNAseq.

2016-02-01 | GSE75354 | GEO

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-02-01 | GSE75356 | GEO

Emergence of neural crest identity is a key early step in melanoma formation [Affymetrix]

Project description:The “cancerized field” concept posits that cells of a given tissue share a potentially oncogenic mutation or insult and are thus cancer-prone, yet only discreet clones within the field initiate tumor formation. In melanoma, tumors frequently (~50%) carry the oncogenic BRAFV600E mutation that is also nearly always present in benign nevi that rarely become melanoma. The zebrafish crestin gene is expressed embryonically in neural crest progenitors and is then specifically re-expressed in melanoma tumors. Here, we show by live imaging transgenic zebrafish crestin reporters that single melanocytes in a cancerized field with oncogenic BRAFV600E and p53 tumor suppressor loss undergo a change that recapitulates the neural crest progenitor (NCP) state, and patches of these cells initiate early melanoma. The crestin element is regulated by the NCP transcription factor sox10. Forced sox10 overexpression in melanocytes accelerated melanoma formation, consistent with reprogramming to the NCP state and activation of super-enhancers that lead to melanoma. Our work highlights the importance of the reemergence of the NCP state as a barrier to melanoma initiation.

2016-06-08 | GSE61823 | GEO

Emergence of neural crest identity is a key early step in melanoma formation [ChIP-Seq]

2016-06-08 | GSE61825 | GEO

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [zebrafish RNA-Seq]

Project description:We report gene expression data for FACS sorted zebrafish crestin_1kb:EGFP + cells collected at 15 somite stage (SS).

2016-02-01 | GSE75355 | GEO

Melanoma cell lines

Project description:5 melanoma cell lines: MelJUSO, A375, 607B, 518A2, Skmel 28 Keywords: other

2004-10-19 | GSE1845 | GEO

Expression data from A375 melanoma parental and persister cells

Project description:Identify transcriptionnally and translationally regulated mRNA in melanoma parental and persister cells In this dataset, we include expression data of A375 melanoma drug-naïve parental cells and A375 melanoma persister cells that survived from BRAF and MEK inhibition. The expression data are studied in both total RNA and polysome-bounded RNA.

2019-09-20 | GSE137724 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data