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Gene expression analysis of CMV infected human fibroblasts in two cultures with differing sensitivity to the virus

ABSTRACT: Analysis of gene expression patterns in cytomegalovirus infected human fibroblasts for two cultures with differing sensitivity to the virus

ORGANISM(S): Homo sapiens

PROVIDER: GSE75366 | GEO | 2015/11/25

SECONDARY ACCESSION(S): PRJNA304033

REPOSITORIES: GEO

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Gene expression analysis of CMV infected human fibroblasts in two cultures with differing sensitivity to the virus

Project description:Analysis of gene expression patterns in cytomegalovirus infected human fibroblasts for two cultures with differing sensitivity to the virus Total RNA obtained from 2 human fibroblast lines with differing sensitivity to CMV infection. For each line 3 types of samples are compared: pre-experimantal norm, 3 hours after infection, 3 hours without infection.

2015-11-25 | E-GEOD-75366 | biostudies-arrayexpress

microRNA expression analysis of CMV infected human fibroblasts in two cultures

Project description:Analysis of microRNA expression patterns in cytomegalovirus infected human fibroblasts for two cultures with differing sensitivity to the virus

2015-11-25 | GSE75305 | GEO

CMV infected human fibroblasts in two cultures with differing sensitivity to the virus

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-11-25 | GSE75383 | GEO

microRNA expression analysis of CMV infected human fibroblasts in two cultures

Project description:Analysis of microRNA expression patterns in cytomegalovirus infected human fibroblasts for two cultures with differing sensitivity to the virus Non-coding RNAs were cloned from total RNA extracts obtained from 2 human fibroblast lines with differing sensitivity to CMV infection. For each line 3 types of samples are compared: pre-experimantal norm, 3 hours after infection, 3 hours without infection.

2015-11-25 | E-GEOD-75305 | biostudies-arrayexpress

CMV infected human fibroblasts in two cultures with differing sensitivity to the virus

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-25 | E-GEOD-75383 | biostudies-arrayexpress

CMV infected human fibroblasts in two cultures with differing sensitivity to the virus

Project description:CMV infected human fibroblasts in two cultures with differing sensitivity to the virus

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

Project description:This SuperSeries is composed of the following subset Series: GSE29772: CNV analysis for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations GSE29773: Gene Expression Data for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Refer to individual Series

2011-07-25 | E-GEOD-29774 | biostudies-arrayexpress

Transcription profiling of human endothelial cells or fibroblasts infected with HCMV virus reveals different cell types have different transcriptional responses

Project description:Human cytomegalovirus infects multiple cell types, including fi-; broblasts and epithelial cells. It penetrates fibroblasts by fusion at; the cell surface but is endocytosed into epithelial cells. In this; report, we demonstrate by electron microscopy that the virus uses; two different routes to enter retinal pigmented epithelial cells,; depending on the cell type in which the infecting virus was; produced. Virus produced in epithelial cells preferentially fuses; with the plasma membrane, whereas fibroblast-derived virus; mostly enters by receptor-mediated endocytosis. Treatment of; epithelial cells with agents that block endosome acidification; inhibited infection by virus produced in fibroblasts but had only a; modest effect on infection by virus from epithelial cells. Epithelial; cell-generated virions had higher intrinsic ââfusion-from-withoutââ; activity than fibroblast-generated particles, and the two virus; preparations triggered different cellular signaling responses, as; evidenced by markedly different transcriptional profiles. We propose; that the cell type in which a human cytomegalovirus particle; is produced likely influences its subsequent spread and its contribution; to pathogenesis. Experiment Overall Design: A single strain of Human Cytomegalovirus (HCMV), termed BADrUL131, was used to prepare viral stocks from either fibroblast cells or from endothelial cells. These viral preparations (fibroBADrUL131 and epiBADrUL131) were used to infect ARP-19 cells (Human retinal pigmented epithelial cells) for either 6 hours or 10 hours. Total RNA was collected, labeled and used to hybridize to Agilent whole genome oligo microarrays and were normalized to a control reference RNA pool.

2008-06-16 | E-GEOD-9578 | biostudies-arrayexpress

Transcriptomic comparison of two barley genotypes differing in arsenic tolerance exposed to arsenate and phosphate treatments

Project description:RNA-sequencing was conducted on the two barley genotypes differing in As tolerance. A total of 2,942 differentially expressed genes (DEGs) were inclusively expressed in both genotypes under As (100µM) and As (100 µM) + P (50 µM).

2018-07-14 | GSE117068 | GEO

Transcriptome profiling in two maize inbreds differing in cold-sensitivity.

Project description:We investigated effect of severe cold on transcriptome changes in two inbred maize lines, chilling-sensitive ETH-DL3 and chilling-tolerant ETH-DH7. Kernels were germinated in wet sand in darkness at 25C. Seedlings were transferred to growth chamber (day/night temperature 24/22C, photoperiod 14/10 h, light 250 umol quanta x m-2 x s-1) and grow in pots containing Knop's nutrient solution supplemented with Hoagland's micro-nutrients. After full development of the 3rd leaf (fully developed ligular region) plants were used in experiment. The experiment was begun at the start of the dark period. Half of the plants were transferred to cold chamber (day/night temperature 8/6C, photoperiod 14/10 h, light 250 umol quanta x m-2 x s-1) other half served as control (day/night temperature 24/22C, other parameters was the same as for cold treatment). After dark period (10h) and 200 minutes of light period samples were taken. Each sample consisted of the middle part of the 3rd leaf blade, pooled from three plants and frozen in liquid nitrogen. The experiment was replicated four times with two replications dye swapped.

2014-03-15 | E-MTAB-1315 | biostudies-arrayexpress

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