A PhoP point mutation discriminates between the virulent H37Rv and avirulent H37Ra strains of Mycobacterium tuberculosis

ABSTRACT: To uncover mutations underlying the attentuation of H37Ra, we embarked on sequencing its genome using a novel massive parallel pyrosequencing technology. Comparison with the virulent H37Rv parental strain revealed only few polymorphisms, one of which was located in the DNA binding domain of the transcriptional regulator PhoP. Keywords: Expresion profiling

OTHER RELATED OMICS DATASETS IN: PRJNA99369

ORGANISM(S): Mycobacterium tuberculosis Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Rv

PROVIDER: GSE7539 | GEO | 2007/07/05

SECONDARY ACCESSION(S): PRJNA99369

REPOSITORIES: GEO