Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from mouse brain tissue

ABSTRACT: Microarrays were performed to assess changes in gene expression following treatment of aged mice with human plasma from donors of different ages (young=19-24 years; old=61-82 years).

ORGANISM(S): Mus musculus

PROVIDER: GSE75416 | GEO | 2017/04/19

SECONDARY ACCESSION(S): PRJNA304158

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data from mouse brain tissue

Project description:Microarrays were performed to assess changes in gene expression following treatment of aged mice with human plasma from donors of different ages (young=19-24 years; old=61-82 years). Aged mice treated with different groups of human plasma were sacrificed following 6 intravenous injections, and hippocampi were dissected from brain tissue for analysis by whole genome microarray.

2017-04-19 | E-GEOD-75416 | biostudies-arrayexpress

Epigenome analysis of aging muscle progenitors

Project description:Genome wide DNA methylation profiling of muscle cells extracted from healthy donors at different ages. The Illumina Infinium Human Methylation 450 BeadChip was used to obtain DNA methylation profiles across > 485,000 methylation sites. The muscle cells were extracted from young adults (18-40 years old) and elderly (>70 years old)(n=3 per group, 2 groups : Young and aged adult).

2015-05-01 | GSE53302 | GEO

Epigenome analysis of aging muscle progenitors

2015-05-01 | E-GEOD-53302 | biostudies-arrayexpress

Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

Project description:While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets are infected with SARS-CoV-2. Although SARS-CoV-2 is isolated from all ferrets regardless of age, aged ferrets (≥3 years old) shows higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration and clinical symptoms compared to juvenile (≤6 months) and young adult (1-2 years) groups. Furthermore, direct contact ferrets co-housed with the virus-infected aged group shed more virus than direct-contact ferrets co-housed with virus-infected juvenile or young adult ferrets. Transcriptome analysis of aged ferret lungs reveals strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2.

2021-12-31 | GSE189619 | GEO

Affy_Human plasma_aged mice

Project description:Aged NSG mice treated with different groups of human plasma were sacrificed at the indicated time and hippocampi were dissected from brain tissue for analysis by whole genome microarray. Human plasma groups included cord, young, and elderly plasma with PBS (vehicle) as control. In light of recent studies showing that young mouse plasma can alter aging of aged brain and other tissue, we sought to assess whether there was revitalizing activity present within human plasma of different ages.

2017-04-21 | E-MTAB-4087 | biostudies-arrayexpress

Gene Expression Data in Human Monocyte-derived Dendritic Cell (MoDC) from Young and Aged Donors

Project description:Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs changes with age. The purpose of this study was to define the age-associated molecular changes in DCs by gene array analysis using Affymatrix GeneChips. We identified up and down-regulated gene expression changes in DC from aged donors compared to young donors. Total 9 MoDC RNA samples from four young donors (20-27 years) and five aged donors (77-84 years) were analyzed using Affymetrix HG-U133A_2 Gene Arrays to compare differential gene expression changes in MoDC between aged and young groups

2014-05-28 | E-GEOD-58015 | biostudies-arrayexpress

Brain endothelial cells are exquisite sensors of age-related circulatory cues

Project description:single cell RNAseq of brain endothelial cells in normal aging, aged and young plasma treatment, and LPS treatment

2020-03-05 | GSE146395 | GEO

Study of gene expression of peripheral blood T cells in 25 healthy male donors of different age from 25 to 97 years

Project description:In this study we analyse a gene expression dataset, obtained by microarray hybridization, consisting of T lymphocytes from 25 healthy male volunteers with ages ranging over whole adult lifespan (25 to 97 years). Large groups of genes exhibiting non-monotonic expression patterns over time were observed, highlighting similarities in gene expression profiles of young and ‘‘successfully aged’’ individuals.

2017-06-10 | GSE99855 | GEO

Tear proteomics of young patients wearing glasses, orthokeratology lenses, and soft contact lenses

Project description:Contact lens-related ocular surface complications occur more often in teenagers and young adults. The purpose of this study was to determine changes in tear proteome of young patients wearing glasses (GL), orthokeratology lenses (OK), and soft contact lenses (SCL). Twenty-two young patients (10-26 years of age) who were established (> 3 years) GL (n=10), OK (n=6), and SCL (n=6) wearers were recruited. Tears were collected via Schirmer strips. Proteomic data were collected using a data-independent acquisition-parallel accumulation serial fragmentation (diaPASEF) workflow. Tear proteome composition and abundance were compared across different correction groups and between the children (age <18 years) and young adults (age 18 years) GL wearers. We identified 3406 protein groups in tears. Among proteins identified in 80% of tear samples, 8 proteins were upregulated, and 11 proteins were down-regulated in the SCL group compared to the OK group. Eighty-two proteins were differentially expressed in children and young adults GL wearers, among which 67 proteins were upregulated, and 15 proteins were downregulated in children. These 82 proteins were involved in 1 inflammation, 9 immune, and 1 glycoprotein metabolic biological processes. As teenagers and young adults have the highest risk of developing contact lens-related complications, this work highlights the importance of understanding ocular responses to contact lens wear across different ages.

2022-11-07 | PXD029188 | Pride