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Analysis of altered mRNA expression profiles in the genetic hypercalciuric stone-forming (GHS) rat compared to normal SD rat

ABSTRACT: Urolithiasis is a common desease to human beings, and idiopathic hypercalciuria (IH) is an important risk factor of calcium urolithiasis, previous studies strongly suggested that the decreased tubular Ca2+ reabsorption played a key role of hypercalciuria. However,the molecular mechanism of IH-urolithiasis formation is still not completely elucidated. GHS rat is regarded as an ideal animal model of calcium urolithiasis, reveals many identical pathophysiologic characteristics with IH patients . We analyzed mRNA expression profiles of the kidney of GHS rat in order to find out the target genes and signaling pathways in the pathogenesis of IH. Overall design: The colony of GHS rats were created by the selective breeding of male and female SD rats with the highest 24 hour urine excretions (doi: 10.3390/ijms160716313). In the 28 generation, GHS rats have stabilized excreted significant higher level of urine calcium than wild-type normal SD rats, and reveals many identical pathophysiologic characteristics with IH patients, such as normal serum Ca2+, hypercalciuria, elevated intestinal Ca2+ resorption and a tendency to lose calcium from the bone. This present study examined the mRNAs expression of three pairs of GHS rats’ kidneys with normal SD rats by microarrays.

INSTRUMENT(S): [RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version]


PROVIDER: GSE75542 | GEO | 2015-12-01



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Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney.

Lu Yuchao Y   Qin Baolong B   Hu Henglong H   Zhang Jiaqiao J   Wang Yufeng Y   Wang Qing Q   Wang Shaogang S  

PeerJ 20160331

Background. MicroRNAs (miRNAs) influence a variety of biological functions by regulating gene expression post-transcriptionally. Aberrant miRNA expression has been associated with many human diseases. Urolithiasis is a common disease, and idiopathic hypercalciuria (IH) is an important risk factor for calcium urolithiasis. However, miRNA expression patterns and their biological functions in urolithiasis remain unknown. Methods and Results. A multi-step approach combining microarray miRNA and mRNA  ...[more]

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