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Gene expression in mouse cerebral cortex in response to short-term calorie restriction

ABSTRACT: The effect of a short-term calorie restricted diet was evaluated in cerebral cortex in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

ORGANISM(S): Mus musculus

PROVIDER: GSE75569 | GEO | 2017/05/31

SECONDARY ACCESSION(S): PRJNA304623

REPOSITORIES: GEO

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Gene expression in mouse liver in response to short-term calorie restriction

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Gene expression in mouse heart in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in heart in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

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Gene expression in mouse gastrocnemius muscle in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in gastrocnemius muscle (GASTROC) in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

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Gene expression in mouse liver in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in six strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age Tissues were collected from mice at 22 weeks of age; there were 96 microarrays used in total: for each of the 6 strains of mice, there were 8 control-fed mice and 8 calorie restricted mice (one individual mouse per microarray)

2013-09-26 | E-GEOD-50789 | biostudies-arrayexpress

Gene expression in mouse epididymal white adipose tissue in response to short-term calorie restriction

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Gene expression in mouse hippocampus in response to long-term calorie restriction

Project description:The effect of a long-term calorie restricted diet was evaluated in hippocampus of male mice The dietary intervention was initiated at 14 months of age and continued until 30 months of age

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Gene expression in mouse kidney in response to long-term calorie restriction

Project description:The effect of a long-term calorie restricted diet was evaluated in kidney of male mice The dietary intervention was initiated at 14 months of age and continued until 30 months of age

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Gene expression in gastrocnemius muscle in response to calorie restriction in wildtype and Sirt3 knockout mice

Project description:The effect of calorie restriction from two to 12 months of age was evaluated in gastrocnemius muscle in both wildtype mice as well as Sirt3 knockout mice The dietary intervention was initiated at 2 months of age and continued until 12 months of age

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Calorie restriction and aging

Project description:Gene expression profiles of kidney tissue from control-fed 5-month-old, control-fed 30-month-old and calorie restricted 30 month-old C57BL/6 mice. Keywords = kidney, aging, calorie restriction Keywords: other

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Comparison of hepatic gene expression between short-term calorie restricted wild-type and Dgat1 deficient middle-aged female mice

Project description:Leanness is associated with increased lifespan and is linked to favorable metabolic conditions promoting life extension. We show here that deficiency of the lipid synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which reduces body fat in mice, promotes longevity. Female DGAT1-deficient mice were protected from age-related increases in body fat, non-adipose tissue triglycerides, and markers of inflammation in white adipose tissue. These metabolic changes were accompanied by an increased mean and maximal lifespan of ~25% and ~10%, respectively. The gene expression profile of DGAT1-deficient mice was not highly correlated with calorie restriction of sex and age matched wild-type littermates. Our findings indicate that loss of DGAT1-mediated lipid synthesis results in leanness, protects against age-related metabolic consequences, and thus extends longevity. Liver gene expression profiles between short-term calorie restricted wild-type (WTCR) and Dgat1 deficient (KO) middle-aged (15-16 mo) female mice were compared to determine if calorie restriction and Dgat1 deficiency rely on common regulatory pathways for the promotion of longevity. Both CR and KO were compared to middle-aged wild-type female littermates fed a standard chow diet ad libitum (WTAL).

2012-02-09 | E-GEOD-26267 | biostudies-arrayexpress

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