DNA repair in species with extreme lifespan differences

ABSTRACT: We compared RNA-seq expression patterns in liver, an organ with high oxidative metabolism and abundant spontaneous DNA damage, from humans, naked mole rats, and mice, differing in maximum lifespan over a range of ~100, 30, and 3 years, respectively, for 130 genes involved in DNA repair. The results show that the longer-lived species, human and naked mole rat, share higher expression of these DNA repair genes, including core genes in several DNA repair pathways. A more systematic approach of signaling pathway analysis (SPA) indicates statistically significant upregulation of several DNA repair signaling pathways in human and naked mole rat compared with mouse.

OTHER RELATED OMICS DATASETS IN: PRJNA304727

ORGANISM(S): Mus musculus Homo sapiens Heterocephalus glaber

PROVIDER: GSE75606 | GEO | 2015/12/03

SECONDARY ACCESSION(S): PRJNA304727

REPOSITORIES: GEO