Transcriptomics,Genomics

Dataset Information

25

Transcriptomic profiling of HeLa cells infected with Shigella flexneri


ABSTRACT: We evaluated the transcriptome changes induced by infection of Hela 229 cells with Shigella flexneri. The sample set consists of a control (mock), total population of infected sample and infected sample sorted into Shigella positive and Shigella negative population. Overall design: Transcriptmic profiles of HeLa cells infected with Shigella were generated by high throughput sequencing using Illumina HiSeq2000.

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Ana Eulalio  

PROVIDER: GSE75746 | GEO | 2017-04-04

SECONDARY ACCESSION(S): PRJNA305266

REPOSITORIES: GEO

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Publications

Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia.

Sunkavalli Ushasree U   Aguilar Carmen C   Silva Ricardo Jorge RJ   Sharan Malvika M   Cruz Ana Rita AR   Tawk Caroline C   Maudet Claire C   Mano Miguel M   Eulalio Ana A  

PLoS pathogens 20170410 4


MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysentery in humans. Specifically, we characterize the dual regulatory role of miR-29b-2-5p during infection, showing that this microRNA strongly favors Shigella infection by promoting bot  ...[more]

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