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Identification of endothelial genes co-regulated upon endothelial Evi/Wls and Rspo3 deletion

ABSTRACT: Inducible endothelial Rspo3 deletion resulted in perturbed developmental and tumor vascular remodeling. Rspo3-iECKO mice strikingly phenocopied the non-canonical WNT signaling-induced vascular defects of mice deleted for the WNT secretion factor Evi/Wls. An endothelial screen for RSPO3 and EVI/WLS co-regulated genes identified novel target genes, which could be linked to WNT/Ca2+/NFAT signaling. In summary, the study identifies endothelial RSPO3-driven non canonical WNT/Ca2+/NFAT signaling as critical maintenance pathway of the remodeling vasculature.

ORGANISM(S): Mus musculus

PROVIDER: GSE75836 | GEO | 2016/02/03

SECONDARY ACCESSION(S): PRJNA305530

REPOSITORIES: GEO

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