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ILC progenitor CEL-seq

ABSTRACT: Here we identify the c-kit+ CILP population which generates all ILC subsets including NK cells, and the CD25- ILC2-restricted Sca-1+ CILP. We mapped the transcriptional changes that occur in ILC progenitor commitment identifying new regulatory factors and provide a map for early ILC differentiation. Finally, we mapped the subsequent transcriptional changes that occur in c-kit+ CILP in absence of Id2 and Tcf7, key regulators downstream of Nfil3.

ORGANISM(S): Mus musculus

PROVIDER: GSE75851 | GEO | 2016/10/04

SECONDARY ACCESSION(S): PRJNA305531

REPOSITORIES: GEO

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