Neuromedin U promotes a malignant phenotype in luminal breast cancer involving Naked 2 (NKD2) modulated WNT signalling

ABSTRACT: Neuromedin U (NMU), which is thought to contribute to putative metastasis processes in various tumor entities, was identified as being up-regulated in breast cancer. Therefore, we aimed to uncover the role of NMU in breast cancer subtypes deciphering for the first time NMU-driven signalling pathways and downstream targets. Stable gain-of-function in vitro models were generated to decipher the biological role of NMU in breast cancer cells. To uncover underlying signalling pathways and key molecules affected by NMU in the luminal-like SKBR3 model, microarray analysis was carried out.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75932 | GEO | 2017/08/13

SECONDARY ACCESSION(S): PRJNA305734

REPOSITORIES: GEO