Transcriptomics,Genomics

Dataset Information

150

HeLa transcriptome induction by IFN gamma and indoleamine 2,3-dioxygenase (IDO)


ABSTRACT: We describe the modulation of gene expression by IDO induction in HeLa cells. Overall design: The RNA-seq transcriptome profile of IFN gamma-treated and IDO1-transduced HeLa cells was compared to that of untreated WT and GFP-transduced HeLa cells, respectively.

INSTRUMENT(S): Illumina HiSeq 1000 (Homo sapiens)

SUBMITTER: Stephen Taylor  

PROVIDER: GSE75956 | GEO | 2017-02-09

SECONDARY ACCESSION(S): PRJNA305853

REPOSITORIES: GEO

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Publications

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.

Timosenko Elina E   Ghadbane Hemza H   Silk Jonathan D JD   Shepherd Dawn D   Gileadi Uzi U   Howson Lauren J LJ   Laynes Robert R   Zhao Qi Q   Strausberg Robert L RL   Olsen Lars R LR   Taylor Stephen S   Buffa Francesca M FM   Boyd Richard R   Cerundolo Vincenzo V  

Cancer research 20160920 21


Tryptophan degradation is an immune escape strategy shared by many tumors. However, cancer cells' compensatory mechanisms remain unclear. We demonstrate here that a shortage of tryptophan caused by expression of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) resulted in ATF4-dependent upregulation of several amino acid transporters, including SLC1A5 and its truncated isoforms, which in turn enhanced tryptophan and glutamine uptake. Importantly, SLC1A5 failed to be upregul  ...[more]

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