Genomics

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SIRT1 dosage-dependent effects on cell proliferation and metabolism


ABSTRACT: The goal of this project is to understand the dosage-dependent effects of SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, on cell proliferation and metabolism. Our recent studies indicate that SIRT1 has a dosage-dependent effect on cell metabolism and proliferation. Heterozygous deletion of SIRT1 enhance glycolysis and glutaminolysis, thereby promoting cell proliferation and stress resistance. Yet homozygous deletion of SIRT1 triggers cellular apoptotic pathways, leading to increased cell death. To understand the molecular mechanisms underlying this dose-dependent effect, we examined the transcriptomes of SIRT1 WT, Het, and KO MEFs cultured in complete DMEM medium by microarray analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE76088 | GEO | 2016/12/20

SECONDARY ACCESSION(S): PRJNA306237

REPOSITORIES: GEO

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