Transcriptomics,Genomics

Dataset Information

147

Initial seeding of the embryonic thymus by an immune-restricted lympho-myeloid progenitor independently of Notch signaling


ABSTRACT: Gene expression analysis of purified thymopoiesis-initiating progenitors/early thymic progenitors, lymphoid primed multipotent progenitors (LMPP) and hematopoietic stem/progenitor cells from E11.5, E12.5, E13.5 embryos, neonatal (1 week old) and adult (8 weeks old) mice Overall design: Differentially expressed genes analysis

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Supat Thongjuea  

PROVIDER: GSE76140 | GEO | 2016-09-26

SECONDARY ACCESSION(S): PRJNA306426

REPOSITORIES: GEO

altmetric image

Publications


The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functional and molecular properties of embryonic thymopoiesis-initiating progenitors (T-IPs) before their entry into the thymus and activation of Notch signaling. T-IPs did not include mul  ...[more]

Similar Datasets

| GSE100618 | GEO
| GSE84677 | GEO
2015-09-01 | E-GEOD-60448 | ArrayExpress
2013-11-26 | E-GEOD-50896 | ArrayExpress
| GSE67034 | GEO
2017-10-03 | E-MTAB-5456 | ArrayExpress
| GSE77740 | GEO
| GSE69789 | GEO
| GSE77736 | GEO
2014-02-18 | E-GEOD-55076 | ArrayExpress