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Effect of high-sugar feeding on wandering third instar larval fat body gene expression in Drosophila melanogaster

ABSTRACT: We compared gene expression in the Drosophila fat body on control and high-sugar diets in order to gain insight into the role of this organ during caloric overload. Differential expression analysis revealed changes in gene expression suggestive of a role for CoA metabolism in the ability to tolerate high-sugar feeding. This led us to perform biochemical and mutant studies supporting a model where CoA is limiting in the face of caloric overload.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE76214 | GEO | 2016/01/27

SECONDARY ACCESSION(S): PRJNA306649

REPOSITORIES: GEO

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